International Academy of Cardiology Annual Scientific Sessions 2017 22nd World Congress on Heart Disease

Annual Scientific Sessions 2017
22nd World Congress on Heart Disease

Hyatt Regency Vancouver

Vancouver, BC, Canada

July 14-16, 2017

 

Vancouver Canada place_Panoramic

NEJM: Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure

Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure — NEJM

Conclusions

In this trial, prophylactic ICD implantation in patients with symptomatic systolic heart failure not caused by coronary artery disease was not associated with a significantly lower long-term rate of death from any cause than was usual clinical care. (Funded by Medtronic and others; DANISH ClinicalTrials.gov number, NCT00542945.)

Effects of salidroside on myocardial cell apoptosis in acute myocardial ischemia rats and its mechanism

Effects of salidroside on myocardial cell apoptosis in acute myocardial ischemia rats and its mechanism

Authors: Jie Li, Jun-Feng Li, Ting-Ting Wei, Jun-Hua Li

Abstract

Background: To observe the effects of salidroside on myocardial cell apoptosis in acute myocardial ischemia (AMI) rats and explore its possible molecular mechanisms.
Methods: Sprague-Dawley (SD) rat models of AMI were established and randomized into salidroside high-dose (40 mg/kg) and low-dose (10 mg/kg) groups, AMI group, and sham group. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining was applied to analyze the myocardial cell apoptosis. Western blotting was used to determine the protein expressions of Bcl-2, Bax, Cytochrome c (Cyt-c), cleaved caspase-3, and cleaved caspase-9.
Results: TUNEL staining showed that salidroside inhibited AMI-induced myocardial cell apoptosis in a dose-dependent manner. Moreover, compared with AMI group, the salidroside treatment groups had significantly increased protein expression of Bcl-2 and significantly decreased protein expression of Bax, Cyt-c, cleaved caspase-3, and cleaved caspase-9.
Conclusions: Salidroside inhibits myocardial cell apoptosis during AMI, which may be achieved by inactivating the mitochondria-dependent pathway. This finding may provide labarotary evidence for the clinical application of salidroside in treating ischemic heart disease.

journal: Xiangya Medicine

blogcdtjournal

XYM cover

Xiangya Medicine: embracing change and recording medical progress

We are excited to introduce our newest journal, Xiangya Medicine (Xiangya Med; XYM), as the first English-language medical journal named after Xiangya Hospital. The journal is based on the history and traditions of the Xiangya Medical System. As an experienced international publisher, AME Publishing Company, is proud to record medical progress from within Xiangya Medical System and around the world.

Xiangya Hospital was established in 1906 by the Yale-China Association of the United States. It has been providing care and education in accordance with the highest standards of western medical colleagues since its establishment. XYM is designed as an international journal to enhance visibility of the Xiangya Medical System. Its editorial board will include local and international opinion leaders. Published with a model of open access and rigorous peer review, the journal will serve as a platform for…

View original post 19 more words

journal: Xiangya Medicine

XYM cover

Xiangya Medicine: embracing change and recording medical progress

We are excited to introduce our newest journal, Xiangya Medicine (Xiangya Med; XYM), as the first English-language medical journal named after Xiangya Hospital. The journal is based on the history and traditions of the Xiangya Medical System. As an experienced international publisher, AME Publishing Company, is proud to record medical progress from within Xiangya Medical System and around the world.

Xiangya Hospital was established in 1906 by the Yale-China Association of the United States. It has been providing care and education in accordance with the highest standards of western medical colleagues since its establishment. XYM is designed as an international journal to enhance visibility of the Xiangya Medical System. Its editorial board will include local and international opinion leaders. Published with a model of open access and rigorous peer review, the journal will serve as a platform for healthcare professionals to share precious clinical experience, novel research results, cutting edge technological findings, up-to-date information and profound analysis.

gocavs